Primate social behavior as a method of analysis of drug action: studies with THC in monkeys.
نویسندگان
چکیده
The use of primate social behavior tests systems to characterize alteration of central nervous system (CNS) function by lesioning, telestimulation, and psychoactive drugs is discussed. Current observations of effects of acute and long-term chronic administration of delta9-tetrahydrocannabinol in group-caged rhesus monkeys are cited to demonstrate the sensitivity and specificity of primate social behavior test systems in characterization of CNS drugs. The time course of drug action proceeds from the acute intoxication stage (sedation, stimulation, decreased social interaction) through behavioral tolerance to the emergence of irritable aggressiveness (which is demonstrated in four different social contexts). The influence of social enviornmental factors and individual differences in social roles on the manifestation of drug effects are discussed. Possible mechanisms of drug action (on biogenic amines and synaptic receptors) compatible with the behavioral data are suggested.
منابع مشابه
جامعهشناسی مصرف مواد مخدر
In this article which is a review of sociological ideas and studies of drug abusers in social situation, drug addiction steps (particularly alcohol, heroin and cocaine consumption) are revised and some explanations are made. Also, the role of some sociological ideas in drug addiction is considered in which Anomie Theory reads: "because of such duality, the individuals who are not satisfied with...
متن کاملA Meta-Analysis of the Factors Affecting Drug Trafficking and Strategies to Deal with it during 2006 to 2017 in Tehran *
Objective: The present study aimed to conduct a meta-analysis of factors affecting drug trafficking and strategies to deal with it from 2006 to 2017 in Tehran. Method: The research method was meta-analysis. A total of 18 studies in the field of drug trafficking were identified through searching on the Internet in domestic databases and in organizations and universities in Tehran, and finally, d...
متن کاملShort-latency category specific neural responses to human faces in macaque inferotemporal cortex
In this article I would present evidence to show that timing of the flow of neural signals within the ventral visual stream is a crucial part of the neural code for categorization of faces. We recorded the activity of 554 inferotemporal neurons from two macaque monkeys performing a fixation task. More than 1000 object images including human and non-primate animal faces were presented up to 10 t...
متن کاملDiscriminative Stimulus Effects in Monkeys
Products containing naphthalen-1-yl-(1-pentylindol-3-yl) methanone (JWH-018) and naphthalen-1-yl-(1-butylindol-3-yl) methanone (JWH-073) are emerging drugs of abuse. Here, the behavioral effects of JWH-018 and JWH-073 were examined in one behavioral assay selective for cannabinoid agonism, rhesus monkeys (n 4) discriminating -tetrahydrocannabinol ( -THC; 0.1 mg/kg i.v.), and another assay sensi...
متن کاملRole of basal stress hormones and amygdala dimensions in stress coping strategies of male rhesus monkeys in response to a hazard-reward conflict
Objective(s): In the present study the effect of stress on monkeys that had learned to retrieve food from a five-chamber receptacle, as well as the relationship between their behavior and the serum cortisol and epinephrine levels and relative size of the amygdala was evaluated. Materials and Methods: Six male rhesus monkeys were individually given access to the food reward orderly. They could e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Federation proceedings
دوره 35 11 شماره
صفحات -
تاریخ انتشار 1976